Michael J. Shelley
I direct the Center for Computational Biology at the Flatiron Institute, and am a Senior Research Scientist in the Biophysical Modeling group. I am also a mathematics professor at the Courant Institute of New York University where I co-founded the Applied Math Lab. My research focuses on self-organizational processes in biology and soft-matter physics using the tools of mathematical modeling, analysis, the development of numerical methods, and large-scale simulation.
My Google Scholar page
Recent News
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Our paper with the Irvine Lab (UChicago) graces the cover of January 1 issue of Nature Physics
Panyu Chen, Scott Weady et al (2025)
News and Views: Spinning into New Regimes
by K.A. Takeuchi
- Biophysical Modeling and CCB are looking for excellent postdoc candidates (apply here)
- 02/03/2025, Mike delivers the Physics Colloquium at Queens College.
- 12/06/2024, Mike delivers the Frederic and Julia Wan Distinguished Lecture at UC-Irvine.
- 12/04/2024, Mike gives the qBio Seminar at UCSD.
- 11/04/2024-11/08/2024 Mike is on the Midwest Mechanics Tour giving talks at U. Michigan, Michigan State, Notre Dame, U. Chicago, and U. Wisconsin.
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SF has written a very nice description on our work on self-inhibiting growth:
Claustrophobic Cells Slow Their Own Growth, Forming Beautiful Patterns of Concentric Circles.
Here is another from SciTechDaily:
When Cells Get Stressed, They Create Mesmerizing Growth Patterns.
See the paper Mechanics and Morphology of Proliferating Cell Collectives with Self-Inhibiting Growth, by S Weady, B Palmer et al, in Physical Review Letters 2024.
Read here about vortlets in phys.org:
Some Recent Publications
- P Chen, S Weady, S Atis, T Matsuzawa, MJ Shelley, WTM Irvine, Self-propulsion, flocking and chiral active phases from particles spinning at intermediate Reynolds numbers, in Nature Physics, 2025.
- Y-N Young, V Gomez Herrera, HZ Huan, R Farhadifar, MJ Shelley, A geometric model for dynamics of motor-driven centrosomal asters, in Physical Review Research, 2025.
- MJ Shelley, Flows, self-organization, and transport in living cells, in Physical Review Fluids, 2024.
- S Maddu, V Chardès, MJ Shelley, Inferring biological processes with intrinsic noise from cross-sectional data, arXiv, 2024. > arXiv
- O Jain, B Chakrabarti, R Farhadifar, ER Gavis, MJ Shelley, SY Shvartsman, Geometric Effects in Large Scale Intracellular Flows, arXiv, 2024. arXiv
- DB Stein, MJ Shelley, Computational tools for cellular scale biophysics, in Current Opinion in Cell Biology, 2024.
- S Weady, Palmer, A Lamson, T Kim, R Farhadifar, MJ Shelley, Mechanics and morphology of proliferating cell collectives with self-inhibiting growth, in Physical Review Letters, 2024 (editor's choice).
- A Rautu, A Zidovska, MJ Shelley, Spatio-temporal dynamics of nucleo-cytoplasmic transport, in Physical Review Research, 2024.
- B Chakrabarti, M Rachh, SY Shvartsman, MJ Shelley, Cytoplasmic stirring by active carpets, in Proceedings of the National Academy of Science, 2024.
- S. Weady, D.B. Stein, A. Zidovska, M.J. Shelley, Conformations, correlations, and instabilities of a flexible fiber in an active fluid, in Physical Review Fluids, 2024.
- M Anjur-Dietrich, V Gomez Hererra, R Farhadifar, H-Y Wu, H Merta, S Bahmanyar, MJ Shelley, DJ Needleman, Mechanics of spindle orientation in human mitotic cells is determined by pulling forces on astral microtubules and clustering of cortical dynein, in Developmental Cell, 2024.
- S Maddu, S Weady, MJ Shelley, Learning fast, accurate, and stable closures of a kinetic theory of an active fluid, in Journal of Computational Physics, 2024.
- S Dutta, R Farhadifar, W Lu, G Kabacaoglu, R Blackwell, DB Stein, M Lakonishok, V Gelfand, SY Shvartsman, MJ Shelley, Self-organized intracellular twisters, in Nature Physics, 2024.
- H-Y Wu, G Kabacaoğlu, E Nazockdast, H-C Chang, MJ Shelley, DJ Needleman, Laser ablation and fluid flows reveal the mechanism behind spindle and centrosome positioning, in Nature Physics, 2024.