Reza Farhadifar, Ph.D.

I'm a Research Scientist in the Center for Computational Biology at the Flatiron Institute . My background is in theoretical physics, experimental cell biology, and microscopy. My research combines biophysics, cell biology, and genomics by using quantitative measurements and theoretical modeling to study the underlying principles of size control and scaling in biology. I received my Ph.D. from Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.

Research

Papers

  1. Nabila Founounou, Reza Farhadifar, Giovanna M Collu, Ursula Weber, Michael J Shelley, Marek Mlodzik, "Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation", Nature communications, 12 (2021), pp. 1-16. PDF
  2. Reza Farhadifar, Che-Hang Yu, Gunar Fabig, Hai-Yin Wu, David B Stein, Matthew Rockman, Thomas Müller-Reichert, Michael J Shelley, Daniel J Needleman, "Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution", eLife, 9 (2020), pp. e55877 PDF
  3. Che-Hang Yu, Stefanie Redemann, Hai-Yin Wu, Robert Kiewisz, Tae Yeon Yoo, William Conway, Reza Farhadifar, Thomas Müller-Reichert, Daniel J Needleman, "Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B", Molecular biology of the cell, 30 (2019), pp. 2503-2514 PDF
  4. Lauren Penfield, Brian Wysolmerski, Michael Mauro, Reza Farhadifar, Michael A Martinez, Ronald Biggs, Hai-Yin Wu, Curtis Broberg, Daniel Needleman, Shirin Bahmanyar, "Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair", Molecular biology of the cell, 29 (2018), pp. 852-868 PDF
  5. Erin I Lewis, Reza Farhadifar, Leslie V Farland, Daniel J Needleman, Stacey A Missmer, Catherine Racowsky, "Use of imaging software for assessment of the associations among zona pellucida thickness variation, assisted hatching, and implantation of day 3 embryos", Journal of Assisted Reproduction and Genetics, 34 (2017), pp. 1261-1269
  6. Reza Farhadifar, José Miguel Ponciano, Erik C Andersen, Daniel J Needleman, Charles F Baer, "Mutation is a sufficient and robust predictor of genetic variation for mitotic spindle traits in Caenorhabditis elegans", Genetics, 203 (2016), pp. 1859-1870 PDF
  7. Reza Farhadifar, Charles F Baer, Aurore-Cécile Valfort, Erik C Andersen, Thomas Müller-Reichert, Marie Delattre, Daniel J Needleman, "Scaling, selection, and evolutionary dynamics of the mitotic spindle", Current biology, 25 (2015), pp. 732-740 PDF
  8. Che-Hang Yu, Noah Langowitz, Hai-Yin Wu, Reza Farhadifar, Jan Brugues, Tae Yeon Yoo, Daniel Needleman, "Measuring microtubule polarity in spindles with second-harmonic generation", Biophysical journal, 106 (2014), pp. 1578-1587 PDF
  9. Reza Farhadifar and Daniel Needleman, "Automated segmentation of the first mitotic spindle in differential interference contrast microcopy images of C. elegans embryos", Mitosis, (2014), pp. 41-45 PDF
  10. Douglas B Staple, Reza Farhadifar, J-C Röper, Benoit Aigouy, Suzanne Eaton, Frank Jülicher, "Mechanics and remodelling of cell packings in epithelia", The European Physical Journal E, 33 (2010), pp. 117-127 PDF
  11. Benoît Aigouy, Reza Farhadifar, Douglas B Staple, Andreas Sagner, Jens-Christian Röper, Frank Jülicher, Suzanne Eaton, "Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila", Cell, 142 (2010), pp. 773-786 PDF
  12. Daniel J Needleman, Reza Farhadifar, "Mitosis: taking the measure of spindle length", Current Biology, 20 (2010), pp. R359-R360 PDF
  13. Katharina P. Landsberg, Reza Farhadifar, Jonas Ranft, Daiki Umetsu, Thomas J. Widmann, Thomas Bittig, Amani Said, Frank Jülicher, Christian Dahmann, "Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary", Current Biology, 19 (2009), pp. 1950-1955 PDF
  14. Reza Farhadifar, Jens-Christian Röper, Benoit Aigouy, Suzanne Eaton, Frank Jülicher, "The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing", Current Biology, 17 (2007), pp. 2095-2104 PDF

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