CCB/CCM Flatiron Institute
Methods, approaches, and benchmarks for extracting conformational heterogeneity from cryo-EM images.
Atomistic and coarse-grained approaches to molecular simulations of microtubules.
Certain biomolecules have evolved to sense their environment. We use computational tools to better understand these mechanisms.
Protein mechanism is dictated by the dynamics of diverse conformational states, with machine learning approaches we can improve our access to these.
Pose estimation is a critical part of solving cryo-EM structures, and our approaches centering on the quaternion adjugate approach improve our ability to estimate the rotation of a 3D object from its 2D projection.
SMBp has a new website! You're looking at it right now! Welcome! Click around and check out all the cool stuff we're working on!
The second cryo-EM heterogeneity challenge was launched in November 2025! Datasets and more information can be found on the website.
Former FRF Chen Lin's work on the DRaM-LHM Framework for Iterative Camera Pose Estimation was selected as a best of ICCV 2025 by Voxel51.
Structural and Molecular Biophysics is currently hiring for a joint FRF position with Biomolecular Design! We are looking for excellent postdoc candidates (apply here).
